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Lutalyse 5 mg/ml Injectable

Strength: 100 ml (20 dose)
Sale price$98.12

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Lutalyse is an effective luteolytic agent for mares and cattle and is used to induce parturition in swine.

What is Lutalyse?
Lutalyse used as a luteolytic agent in cattle, parturition induction in swine, and luteolytic effect in mares. This product contains the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt.

Who is Lutalyse for?
For use in cattle, swine, and mares.

Why use Lutalyse?
Lutalyse has a luteolytic effect on cattle and mares and works to induce parturition in swine.

How does Lutalyse work?
This product uses dinoprost tromethamine to:

  • Control estrous timing in estrous cycling mares or in clinically anestrous mares with a corpeus luteum
  • Induce parturition in swine
  • Induce abortion in non-lactating or feedlot cattle
  • Treat chronic endometriosis (pyometra) and silent (unobserved) estrus in cattle
  • Synchronize estrus in cattle


Active ingredient(s):
Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 9.45 mg added as preservative.

How is Lutalyse sold?
-30 ml -100 ml

What are the side effects of Lutalyse?
Potential side effects include:

In mares:

  • Decrease in rectal temperature
  • Sweating

These effects are transient and are not detrimental.

  • Other potential reactions include:
  • Lying down
  • Locomotor incoordination
  • Abdominal discomfort
  • Increased respiration rate
  • Increased heart rate

These reactions typically occur within 15 minutes of injection and resolve within an hour. Even while experiencing a reaction, mares typically continue eating. In a study of several hundred mares on Lutalyse, a single anaphylactic reaction was reported, but was not substantiated.

In swine:

  • Vomiting (at a dose of 100mg)
  • Salivation
  • Increased vocalization
  • Dyspnea
  • Hyperpnea
  • Tail movements
  • Abdominal muscle spasms
  • Defecation
  • Urination
  • Itching
  • Nesting behaviors
  • Slight incoordination
  • Pruritus
  • Erythema

These reactions are typically short-term (10 minutes to 3 hours) and non-detrimental.

In cattle:

  • Limited salivation

What special precautions are there?

  • Pregnancy status should be determined in mares prior to injection. This medication can induce parturition and abortion.
  • Mares with subacute or acute disorders of the reproductive tract, respiratory system, gastrointestinal tract, or vascular system should not take this medication.
  • Employ aggressive antibiotic treatment at the first sign of injection site infection, whether diffuse or localized.
  • Never administer intravenously.
  • Prostaglandin synthesis can be inhibited with concurrent NSAID use. Do not administer with any other NSAID.
  • Never administer to pregnant cattle, except in cases where abortion is desired.
  • Cattle on progestin will have reduced response to this injection.
  • Never administer to gilts or sows before 3 days of predicted normal farrowing. An increased rate of postnatal mortality and stillbirths can occur.
  • This injection is not effective if it is administered before day 5 following ovulation in mares.
  • A severe localized clostridial infection can occur and, rarely, result in death.
  • Not for use in animals intended for food slaughter.
  • Drug residues can result when administered in any dose greater than approved.
  • No withdrawal period is required before slaughter of swine.
  • No pre-slaughter or milk discard is required for cattle.
  • Do not administer to humans.
  • Keep away from children.
  • Humans with respiratory or bronchial issues, asthmatics, and women of childbearing age must use extreme caution in the handling of this product. In early stages, a woman can be unaware of pregnancy. This medication is easily and readily absorbed into the skin, which can cause bronchospasm and/or abortion.
  • Accidental skin spillage must be immediately washed off using soap and water.

For a copy of the SDS (Safety Data Sheet), technical support, or to report a suspected adverse reaction, Zoetis, Inc. may be contacted at 1-888-963-8471.
For more information about side effect reporting of animal drugs, contact the FDA by calling 1-888-FDA-VETS, or go to

What to do if overdose?
Immediately contact your closest emergency animal hospital.

How can I store Lutalyse?
Store in a dry and cool environment. 68° to 77°F (20° to 25°C) 68° to 77°F

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