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Prazosin is an oral medication prescribed by veterinarians to treat urethral obstructions and hypertension in cats. It can also be used to treat cats with spinal cord injuries and cancers.
Urethral obstructions happen when stones, mucus, or other items create a blockage in the cat’s urethra, and they are unable to urinate. Prazosin is an alpha-1 adrenergic blocker, it acts as a smooth muscle relaxant and can be helpful in relaxing the bladder and reducing spasms which makes it easier for the cat to heal. It can also lower blood pressure by allowing the muscles around some arteries to relax.
Prazosin does not cure the cause of the urinary blockage, therefore along with this treatment a change of diet, and stress management, could be prescribed to help in the long run.
In dogs, Prazosin can be used for treatment of congestive heart failure, and systemic hypertension.
Prazosin compounded oral liquid is given by mouth in liquid form daily with or without food as prescribed by your veterinarian. If your pet vomits after dosing it on an empty stomach, try giving future doses with food.
This medication should be given just as your veterinarian prescribes. It must be measured carefully, and it's best to use the syringe provided to ensure you are able to give the proper dosage required. After dosing your pet, rinse and dry the syringe, and screw the cap tightly onto the bottle.
Prazosin is a prescription medication for treating hypertension and urethral obstructions in cats and dogs. If you have difficulty giving it to your pet, contact your veterinarian for some helpful tips. We recommend washing your hands with soap and water after handling any medication.
Prazosin compounded oral liquid is generally safe, however, the most common side effects can include dizziness, lethargy, vomiting, diarrhea, nausea, or constipation. Fainting can also occur.
Contact your veterinarian immediately if these side effects or allergic reactions continue or become more severe.
Drug Interactions: If your pet is on any of the following medications you should use prazosin with caution:
- Ace Inhibitors: (e.g. enalapril) - When combined may increase the risk for hypotension.
- Amlodipine - When combined may increase the risk for hypotension.
- Beta-Blocking Agents: (e.g. propranolol) - May enhance the postural hypotensive effects seen after the first dose of prazosin.
- Clonidine - When combined may decrease prazosin’s antihypertensive effects.
- Pentoxifylline - When combined may increase risk for hypotension.
- Sildenafil: (and other PDE Inhibitors) - When combined may increase risk for hypotension.
- Telmisartan - When combined may increase the risk for hypotension
- Vasopressors: (e.g., dopamine, norepinephrine) - Prazosin may reduce dopamine pressor effect when combined with these drugs.
- Verapamil - May cause synergistic hypotensive effects when used together with prazosin.
Prazosin should not be given to pets that are hypersensitive to it or other quinazolines. It should be used with caution in pets with chronic kidney disease, or hypotensive conditions, and in dogs that are already experiencing hypotension or are in chronic renal failure. Prazosin may cause a drop in blood pressure. It should not be given to animals that are pregnant.
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